Using Mathematica » Basics
Variables
Set
Variables in Mathematica are simple. Just type a name and give it a value with the equals sign ( = ).
Here we'll set the variable  thisIsAVariable
 thisIsAVariable=10
 10
We can suppress the output by ending the line with a semicolon
 thisIsAVariable=10;
(for those interested, the semi colon denotes that this is a  CompoundExpression  where the return value is  Null )
SetDelayed
A variable can also have a "delayed" value. That is, its value is calculated when requested. Here we'll set the variable  randomValuedVariable .
Use colon-equals ( := ) to do this.
 randomValuedVariable:=RandomReal[];
When we ask for its value, the return value will change every time.
 randomValuedVariable
 0.12257688426972924`
randomValuedVariable
 0.13807713447085046`
Clear
The value of a variable can be removed via  Clear
 Clear[randomValuedVariable]
The variable now has no value
 randomValuedVariable
 randomValuedVariable
Simple expressions
We can use variables in expressions to store values for us.
For example, let's do a simple ideal gas law computation for the volume occupied by 2 mols of ideal gas at one atmosphere of pressure and 273 K.
We'll use Mathematica's built in constant data to get the value R in L atm / mol K.
 R$gasConstant=
  QuantityMagnitude[
    UnitConvert[Quantity["MolarGasConstant"],
      "Liters"*"Atmospheres"/("Moles"*"Kelvins")]
    ]
 0.0820573382679496654`5.937562804821409
Then we can set up our constants:
 n$quantityOfGas=2 (*mols*);
P$externalPressure=1(*atm*);
T$temperatureOfGas=273 (*K*);
And finally calculate our volume:
 V$volumeOccupied=n$quantityOfGas*R$gasConstant*T$temperatureOfGas/P$externalPressure
 44.8033066943005173068`5.937562804821409